Yilin Yoshida, PhD

The role of female sex in the deleterious influence of early-onset T2D on CVD

 

Women with type 2 diabetes (T2D) have a heightened risk of cardiovascular disease (CVD) compared to their male counterparts. The goal of Dr. Yilin Yoshida’s project in the Tulane COBRE in Sex-Based Precision Medicine (SPM) is to investigate the role of female sex in the deleterious influence of early-onset T2D on CVD. Dr. Yoshida leverages intensively phenotyped longitudinal cohorts with repeated measures of clinical data and lifestyle risk factors, cardiovascular imaging for cardiac function and atherosclerosis, and novel metabolomics data to address two specific aims 1) quantify the cumulative burden of T2D on CVD risk in women compared to men and 2) identify sex-specific subgroups of individuals with T2D at high CVD risk. In the COBRE, Dr. Yoshida aimed to develop expertise in precision epidemiology, improve understanding of the sex disparities of diabetic cardiovascular disease (CVD) with a life-course perspective, and optimize diabetic cardiovascular risk prediction.