Kristin Miller, PhD

Influence of biological sex and sex hormones on tissue remodeling and pelvic floor stability

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Dr. Miller’s research program uses a combination of in vivo, in vitro, and in silico approaches to address sex differences in aging, remodeling, and regenerative potential of soft biological tissues. Current work is focused on delineating the key cellular and molecular processes of the pelvic floor to improve current interventions and ultimately prevent pelvic floor disorders. We specifically focus on understanding how biomechanical forces, such as intra-abdominal pressures, induce alterations in smooth muscle cell phenotype, elastic fibers, and fibrillar collagens.