Minolfa C. Prieto, MD, PhD

Sex differences in prorenin receptor signaling in hypertension and diabetes

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Dr. Prieto’s research program utilizes a wide-spectrum of cell molecular biology techniques and different rodent models of experimental hypertension, to assess sex differences in the renin-angiotensin system leading to hypertension and renal injury. The basic science branch of the program focuses on signaling mechanisms mediated by the prorenin receptor during hypertension and type 2 diabetes using in vitro approaches and transgenic mouse models with deficiency of the prorenin receptor in various cell-types. The translational branch seeks to assess the clinical impact of the soluble prorenin receptor in women with type 2 diabetes. The long-term goal of Dr. Prieto’s research program is to elucidate the impact of prorenin receptor and estrogen interactions and underlying signaling on the development of renal injury and cardiovascular complications in women.